A six residue polypeptide has been synthesized to study the proposed biosynthesis of lanthionine. It is shown that this peptide spontaneously cyclizes in a biomimetic fashion via a completely stereoselective intramolecular Michael addition to form (2s, 6R)-lanthionine, as found in naturally occurring lantibiotics.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/30395/1/0000014.pd
