Mantle Cell Lymphoma of Intestine Presenting as Multiple Lymphomatous Polyposis with Intussusception

Abstract

Mantle Cell Lymphoma (MCL) is a distinct clinicopathological subtype of B-cell non-Hodgkin's lymphoma (NHL) accounting for 2-10% of all NHL cases. Gastrointestinal tract (GIT) is the predominant site of extranodal MCL which commonly presents as Multiple Lymphomatous Polyposis (MLP). A 60 year old male presented with pain abdomen, diarrhea and weight loss of two months duration. On colonoscopy multiple polyps were found in the entire colon and rectum. Computed tomography revealed ileo-colic intussusception with nodularity in the lead point. Histopathology suggested features of MCL. On immunohistochemistry, the tumor cells were positive for CD20, CD5, Cyclin D1, negative for CD3, CD10, CD23, and CD45 R