Mantle Cell Lymphoma (MCL) is a distinct
clinicopathological subtype of B-cell non-Hodgkin's
lymphoma (NHL) accounting for 2-10% of all NHL
cases. Gastrointestinal tract (GIT) is the predominant
site of extranodal MCL which commonly presents as
Multiple Lymphomatous Polyposis (MLP). A 60 year
old male presented with pain abdomen, diarrhea and
weight loss of two months duration. On colonoscopy
multiple polyps were found in the entire colon and
rectum. Computed tomography revealed ileo-colic
intussusception with nodularity in the lead point.
Histopathology suggested features of MCL. On
immunohistochemistry, the tumor cells were positive
for CD20, CD5, Cyclin D1, negative for CD3, CD10,
CD23, and CD45 R