Background &Objective: Plaryngoscopy and
tracheal intubation increase not only blood pressure and heart rate but also
Bispectral Index (BIS) of the patients. In this study, hemodynamic and BIS changes were surveyed after tracheal intubation and
during general anesthesia followed by mexiletine prescription .
Materials & Methods: In this study, 50
patients aged between 20 and 60 who were candidates for orthopedic surgery of
the upper limbs were surveyed. They were divided in two groups randomly. Two
hours before induction of anesthesia, case
and control groups received mexiletine 200 mg as capsule and oral placebo,
respectively. Systolic and diastolic blood pressures ,heart rate,
and BIS of both groups were compared before induction and intubation; 1,3 and
10 minutes after intubation; and immediately
, 15, 30, 45, and 60 minutes
after surgical incision.
Results: There was not any significant differences in systolic and
diastolic pressures of the two groups. The heart rate was lower in mexiletine group
compared to control group, 30 minutes after surgical incision and immediately
after extubation (P<0.05). BIS
was significantly more in mexiletine groupcompared to control group
(p<0/05).
Conclusion: It was revealed that
the hemodynamic changes after laryngoscopy and during general anesthesia
were significantly lower in mexiletine group compared to the control group. It`s suggested that the prescription
of this drug leads to the increase of BIS after intubation and during general
anesthesia
