Acrokeratosis Verruciformis of Hopf: A Rare Case Report

Abstract

Acrokeratosis Verruciformis of Hopf (AKV) is rare autosomal dominant cutaneous dermatosis described by Hopf in 1931. It is presented at birth but may appear in early child hood; sometimes the onset may be delayed until fifth decade of life. It usually presents with multiple planar wart – like lesions, typically observed on the dorsal aspect of the hands and feet but may extend on to knees, elbows, forearms and also on other parts of the body. The main differential diagnosis is Darier disease and seborrheic keratosis which has similar presentation. The unique finding of AKV is Church spire elevation of epithelium which differentiates from Darier disease. Due to the scarcity of the cases here we present a case of AKV in a 29 year old male which was diagnosed on clinical examination and confirmed with histopathological examination. We have made an attempt to describe histologic features of AKV with differential diagnosis of these lesions through review of literature