Introduction: The etiology of primary nocturnal enuresis (PNE) is
multifactorial. The effects of genetic and hormonal factors, sleep
disorders, and bladder dysfunction have been claimed. The other
factors include increased urine production at night and impairment of
the circadian rhythm of antidiuretic hormone.
Aim: To investigate renal tubular functions in children with PNE.
Methods: Forty patients with PNE were included in the study. Urine
density, FENa, FEK and TRP were analyzed in daytime and nighttime
urine.
Results: The mean nighttime urine density was 1020.12±7.38 and
the mean daytime urine density was 1013.20±7.11 (p<0.05). There
was no significant difference between daytime and nighttime
values of FENa (0.50±0.48 vs. 0.38±0.33), FEK (2.78±1.04 vs.
2.76±1.52) and TRP (88.5±2.4 vs 86.7±2.8) (p>0.05).
Conclusion: Urine density in children with PNE was lower at night.
However, there was no difference in of FENa, FEK and TRP. Further
studies are needed in order to investigate renal tubular functions in
children with PNE (The Me di cal Bul le tin of Ha se ki 2012; 50: 10-3