A semipinacol rearrangement directed by an enzymatic system featuring dual-function FAD-dependent monooxygenase

Abstract

Nature has invented ingenious ways to biosynthesize biologically active small molecules that have been applied ever since to benefit human life in various ways. During the underlying biosynthetic processes, highly elaborate chemical reactions are often catalyzed by enzymatic systems, thereby enabling transformations under physiological conditions that would require harsh conditions or are hardly possible without enzymatic catalysis. Consequently, understanding novel biochemical transformations is of importance to eventually apply the knowledge gained to generate molecules of interest