UJI AKTIVITAS EKSTRAK ETANOL DAUN KERSEN (Muntingia calabura L.) TERHADAP PENYEMBUHAN LUKA BAKAR PADA KULIT MENCIT PUTIH JANTAN (Mus musculus)

Abstract

Kersen leaves (Muntingia calabura L.) is one kind of plants that have many utilities from bark, fruits to leaves. Kersen leaves contain flavonoids and tannins that have potential as a treatment for skin burn. Kersen leaves is used for a treatment such us for analgesic and anti-inflammatory. This study was an experimental research. The goal of this study was to know the potential of ethanol estracts of Kersen leaves against the healing of burn wounds on the back skin of white male mice. Twenty white male mice and were used in this experiment and were divided into 5 groups: control positive (ointment branded), control negative (vaseline flavum), ethanol extract of kersen leaves in vaseline flavum dose 2.6 mg , 5.2 mg and 10.4 mg . The backs of mice was induced using hot solder modified with stainless steel plate size 1 x 1 cm 2 for 2 seconds and the diameter of the healing skin burns was mensured. The results showed that the percentage of control positive was 100%, control negative (65%), ethanol extract of leaves of kersen dose 2.6 mg (84.3%), dose 5.2 mg (85.3%) and dose 10.4 mg (93.3%). The results of data were analyzed using statistical analysis. One - Sample Kolmogorov - Smirnov Test indicated that the data were normally distributed (0.768 > 0.05), the homogenity test (Test homogeneity of Variances) indicated that the data were not homogeneous (0.016 < 0.05). Kruskal Wallis test showed that five (5) treatment groups were significantly different and have the effect of healing of burn wound on the skin of male white mice (0.012 < 0.05), the Mann- Whitney test showed that the control positive and 10,4mg was significantly different (0.043 < 0.05)