<p><em>Aims. </em>The study was aimed to identify relationships of immune disorders and angiogenesis in patients at different stages of rosacea. <em>Materials and methods. </em>We examined 110 patients with rosacea. The diagnosis was based on diagnostic criteria. We summarized the role of predictors in the development of rosacea. We investigated pro- and anti-infammatory cytokines, vascular endothelial growth actor (VEGF), fbroblast growth factor (FGF) for the detection of immune disorders and angiogenesis. <em>Results. </em>The immune response in patients with rosacea was of mixed Th-1 and Th-2 type which can be markers of chronic autoimmune infammation. Simultaneously with the change in cytokine profle we revealed activation of angiogenesis (high levels of VEGF, FGF).</p>
