Isotopic and chemical data of rocks from the Cachoeirinha suite provide new insights on the Proterozoic evolution of the Rio Negro/Juruena Province in SW Amazonian craton. Six U-Pb and Sm-Nd analyses in granitoid rocks of the Cachoeirinha suite yielded ages of 1587-1522 Ma and T DM model ages of 1.88-1.75 Ga (EpsilonNd values of -0.8 to +1.0). In addition, three post-tectonic plutonic rocks yielded U-Pb ages from 1485-1389 Ma (T DM of 1.77-1.74 Ga and EpsilonNd values from -1.3 to +1.7). Variations in major and trace elements of the Cachoeirinha suite rocks indicate fractional crystallization process and magmatic arc geologic setting. These results suggest the following interpretations: (1) The interval of 1590-1520 Ma represents an important magmatic activity in SW Amazonian craton. (2) T DM and arc-related chemical affinity supportthe hypothesis that the rocks are genetically associated with an east-dipping subduction zone under the older (1.79-1.74 Ga) continental margin. (3) The 1590-1520 Ma age of intrusive rocks adjacent to an older crust represents similar geological framework along the southern margin of Baltica, corroborating the hypothesis of tectonic relationship at that time