Kalska, Hely

Lehikoinen, Sanna

Lipsanen, Jari

Niemi-Pynttäri, Jussi

Pesonen, Ullamari

Stenberg, Jan-Henry

Tuunainen, Arja

Psychiatry Journal

Depression has been shown to be associated with cognitive deficits in various cognitive domains. However, it is still unclear which factors contribute to cognitive impairment. The objective of this study was to find out whether a functional polymorphism in the promoter region of the serotonin transporter (5-HTTLPR) gene is associated with the impairment of cognitive functioning among depressed patients. In a pilot study, a sample of 19 patients with major depressive disorder (MDD) and 19 healthy controls was investigated with an extensive psychiatric and neuropsychological examination. All participants were genotyped for 5-HTTLPR. Depressed patients with the short allele of the 5-HTT promoter region exhibited inferior cognitive performance compared to patients with the long allele polymorphism. In healthy controls, no association between genotype and cognitive performance was found. The result suggests that in MDD patients with the short allele of the 5-HTTLPR polymorphism the vulnerability to cognitive impairment is increased compared to MDD patients without the short allele inheritance. These preliminary findings need to be confirmed in a larger cohort of MDD patients

Hely Kalska

Ullamari Pesonen

Sanna Lehikoinen

Jan-Henry Stenberg

Jari Lipsanen

Jussi Niemi-Pynttäri

Arja Tuunainen

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Association between Neurocognitive Impairment and the Short Allele of the 5-HTT Promoter Polymorphism in Depression: A Pilot Study

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Association between Neurocognitive Impairment and the Short Allele of 5-HTT Promoter Polymorphism in Depression: A Pilot Study.

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Association between Neurocognitive Impairment and the Short Allele of 5-HTT Promoter Polymorphism in Depression: A Pilot Study.

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