The SLITRK genes code for transmembrane proteins that modulate neurite outgrowth. Mutations in these genes cause a variety of neurological disorders. To better understand the different expressions of the SLITRK genes and the similarities that link each gene together, six differences in the gene mutations are compared using multiple phylogenetic optimality criteria in two taxa (Homo sapiens and Rattus norvegicus). This project analyzes the link between each of the different SLITRK gene mutations and the devolvement of neurological disorders. Finding a link between the different gene mutations can help to better understand the mutations and assist in the development of future treatments