A selective palladation: Planar and central chiral cyclophanyl-derived mono- and binuclear N,C-palladacycles are prepared by regioselective ortho-palladation of amine- and imine-functionalized [2.2]paracyclophanes employing stepwise Pd(OAc)2 and LiCl followed by modular treatment with PPh3, PCy3 and (Ph2PCH2)2. The regioselective ortho-palladation mono- and bimetallic product formation was analyzed by detailed spectroscopic techniques, mass spectrometry and unambiguously confirmed by single-crystal X-ray analysis.
In this report, we describe a series of cyclophanyl-derived mono- and binuclear N,C-palladacycles by regioselective ortho-palladation of amine-functionalized [2.2]paracyclophanes. Employing Pd(OAc)2 followed by LiCl and with the subsequent modular treatment of Ph3P, Cy3P, and (Ph2PCH2)2, this strategy allows to prepare stable cyclophanyl-derived planar and central chiral N,C-palladacycles in a highly selective manner. The regioselective ortho-palladation mono- and bimetallic product formation was analyzed by detailed spectroscopic techniques, mass spectrometry and unambiguously confirmed by single-crystal X-ray analysis