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Previous issue date: 2012Universidade Federal de Campina Grande. Departamento Ortodontia. Campina Grande, PB, BrasilUniversidade do Estado de Minas Gerais. MG, Brasil.Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Departamento de Nefrologia. Unidade de Transplante Renal. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ. Brasil.Universidade Federal do Rio de Janeiro. Ortodontia. Rio de Janeiro, RJ, Brasil.There are medications capable of affecting bone metabolism and the rate of tooth movement.
Among these medications are the immunosuppressants, which act by repressing the action of T lymphocytes, however
they can cause bone loss and consequently lead to osteoporosis. Osteoporosis is a common complication following
kidney, heart, liver or lung transplantation. The immunosuppressant treatment for preventing organ rejection
after transplantation, in general, includes glucocorticoids, cyclosporine, tacrolimus, and sirolimus. All these
drugs can have jeopardizing effects on bone mineral homeostasis and consequently influence tooth movement. In
recent years, however, the increasing use of immunosuppressants has raised questions about their effects on bone
metabolism in patients undergoing orthodontic treatment
