Edgard Marcelino de Carvalho Filho. Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. "Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento".Submitted by Ana Maria Fiscina Sampaio ([email protected]) on 2017-04-07T12:51:56Z
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Silva MC HCV HTLV coinfection....pdf: 116203 bytes, checksum: 24e464dc01689486d0e327d8242ac287 (MD5)Approved for entry into archive by Ana Maria Fiscina Sampaio ([email protected]) on 2017-04-07T13:05:39Z (GMT) No. of bitstreams: 1
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Silva MC HCV HTLV coinfection....pdf: 116203 bytes, checksum: 24e464dc01689486d0e327d8242ac287 (MD5)
Previous issue date: 2016CNPq (Universal); Grant sponsor: LIA ProjectFederal University of Bahia. Department of Hepatology. Salvador, BA, BrazilFederal University of Bahia. Department of Hepatology. Salvador, BA, BrazilFederal University of Bahia. Department of Hepatology. Salvador, BA, BrazilFederal University of Bahia. Clinical and Toxicological Analysis. Salvador, BA, BrazilFederal University of Bahia. Immunology Laboratory of the Health Science Institute. Salvador, BA, BrazilFederal University of Bahia. Immunology Service of the University Hospital Professor Edgar Santos. Salvador, BA, BrazilFederal University of Bahia. Hepatology Center of the University Hospital Professor Edgar Santos. Salvador, BA, BrazilFederal University of Bahia. Hepatology Center of the University Hospital Professor Edgar Santos. Salvador, BA, BrazilHepatitis C virus (HCV) and human T-lymphotropic virus type 1 (HTLV-1) coinfection occurs in many regions. However, few studies have focused on the natural history of HCV-induced liver disease in coinfected patients. To describe the clinical, epidemiological, and histopathological aspects of HTLV-1/HCV coinfection in Brazil. A cross-sectional study with 23 patients coinfected with HCV/HTLV. The control groups consisted of 21 patients monoinfected with HCV and 20 patients monoinfected with HTLV-1. The cytokine profiles (Th1 and Th2 cell responses), clinical, laboratory features, and histopathological aspects were examined. The control group for cytokine analysis validation consisted of patients monoinfected with HTLV, and a fourth group consisted of healthy blood donors. No anthropometric differences present between the three infected groups. We observed higher serum concentrations of IFN-γ in patients coinfected with HCV/HTLV-1 than those in HCV monoinfected patients. The HCV/HTLV-1 coinfected group also exhibited a higher degree of liver steatosis than the HCV monoinfected patients. Results suggest that HCV/HTLV-1 coinfection may result in a different pattern of HCV infection due to the immunologic disorders likely associated with HTLV-1, but there is no clear evidence of the HTLV role in the natural history of HCV infection
