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Previous issue date: 2006Federal University of Maranhão. Nucleus of Tropical Pathology and Social Medicine. São Luís, MA, Brasil / University of São Paulo. Faculty of Medicine. Laboratory of Pathology of Infectious Diseases. Department of Pathology. São Paulo, SP, BrasilState University of Maranhão. Faculty of Veterinary Medicine. Laboratory of Histology. São Luís, MA, BrasilUniversity of São Paulo. Faculty of Medicine. Laboratory of Pathology of Infectious Diseases. Department of Pathology. São Paulo, SP, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFederal University of Maranhão. Nucleus of Tropical Pathology and Social Medicine. São Luís, MA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilUniversity of São Paulo. Faculty of Medicine. Laboratory of Pathology of Infectious Diseases. Department of Pathology. São Paulo, SP, BrasilExperimental animal models have been used for the study of the physiopathogenesis of leishmaniasis, on some occasions with
success, while in other situations such as bone alterations that accompany tegumentary leishmaniasis, especially in diffuse cutaneous
form (DCL), the mechanisms are still unknown. In the present study, we determined these alterations in an animal model susceptible
to Leishmania (L) amazonensis. Amastigotes of L. (L) amazonensis isolated from patients with diffuse cutaneous leishmaniasis
(DCL) were inoculated into the hind paws of eight BALB/c mice, macroscopic and histopathological aspects were analyzed. After
90 and 120 days of evolution, histopathological analysis demonstrated a mononuclear cell infiltrate rich in plasma cells and intense
parasitism of intra- and extra-medullary macrophages, with areas of bone necrosis and discrete involvement of cartilaginous tissue.
The results show that the inflammatory process developed during L. (L) amazonensis infection might cause bone tissue destruction
and secondarily affect the joint
