Peptide natural products displaying a wide range of biological activities have become
important drug candidates over the years. Microorganisms have been a powerful source of such
bioactive peptides, and Streptomyces have yielded many novel natural products thus far. In an effort to
uncover such new, meaningful compounds, the metabolome of Streptomyces acidiscabies was analyzed
thoroughly. Three new compounds, scabimycins A–C (1–3), were discovered, and their chemical
structures were elucidated by NMR spectroscopy. The relative and absolute configurations were
determined using ROESY NMR experiments and advanced Marfey’s method