No major association between <it>TGFBR1</it>*6A and prostate cancer

Abstract

<p>Abstract</p> <p>Prostate cancer is the most commonly diagnosed cancer in men and one of the leading causes of cancer deaths. There is strong genetic evidence indicating that a large proportion of prostate cancers are caused by heritable factors but the search for prostate cancer susceptibility genes has thus far remained elusive. <it>TGFBR1</it>*6A, a common hypomorphic variant of the type I Transforming Growth Factor Beta receptor, is emerging as a tumor susceptibility allele that predisposes to the development of breast, colon and ovarian cancer. The association with prostate cancer has not yet been explored. A total of 907 cases and controls from New York City were genotyped to test the hypothesis that <it>TGFBR1</it>*6A may contribute to the development of prostate cancer. <it>TGFBR1</it>*6A allelic frequency among cases (0.086) was slightly higher than among controls (0.080) but the differences in <it>TGFBR1</it>*6A genotype distribution between cases and controls did not reach statistical significance (p = 0.67). Our data suggest that <it>TGFBR1</it>*6A does not contribute to the development of prostate cancer.</p