Objectives: In this study we aimed to prospectively investigate,asthma provoking factors and among thesefactors the place of Hot pepper (Isot) during August-Septembermonths which are time period for processing isot.Methods: In this study, 73 female patients with exacerbationof asthma who applied to Chest Diseases OutpatientClinic and emergency department in the period of August-September (2010) were evaluated prospectively.Results: Seventy-three asthmatic female patients, meansage 34.7±6.1 (22-43) years were included. Patients withexacerbation of asthma provoking factors are; inhalationof isot pepper 28.8%, infections 23.3%, irregular use ofdrugs 16.4%, exposure to biomass and cigarette smoke13.7%, allergens 9.6%, emotional factors 5%, and gastroesophagealreflux 2.7%, physical exercise 1.4%.Conclusion: We observed that the most important asthmaprovoking factor was the inhalation of isot extract inasthmatic female patients in August-September (2010)period in Sanliurfa. J Clin Exp Invest 2013; 4 (3): 331-334Key words: Asthma, hot pepper, Isot, capsaicin, Sanliurf