The present paper studies the vindication of what is human in the thought of Mariano Picón Salas (1901-1965), particularly regarding the author’s ideas in the texts Regreso de tres mundos, Literatura y sociedad, Cultura y soseigo and Vicisitudes en el arte de historiar. In these texts, the search for Picón Salas’ ideals works as a transversal reading which reveals two central ideas according to which the author favours: 1) an aesthetics of the work of art, based on the picture of human condition that only be offered by literature, and 2) the construction of an ethics of reading, a form of interpretation that allows us to see the humane dimension in man’s greatest searches