The assessment of the angiogenesis in the uterine cervix carcinogenesis

Abstract

The uterine carcinoma represents one of the most frequent malignant tumors in female. Great progresses were made in the understanding of the mechanisms of the appearance and evolution of the tumors, and also in the early diagnosis of them. In the present time, the discussions are centered on the angiogenesis and the neovascularisation. During the researches regarding the new factors of prognosis in cervical carcinomas, we are interesting firstly in the study of neoangiogenesis and its predictive role. The microanatomic quantitative study was made on fragments which were processed from uterine cervix dysplasias, preinvasive and invasive tumors. The sections were stained specific immunohistochemically (CD34) and examined with an interactive digital program. We have quantified the density of the microvessels/mm2 tumor stroma and the density of the microvessels/mm2 tumor. The preliminary results regarding the study of the microvessels in uterine cervix carcinomas show a positive correlation between the density and the evolution of the tumor, the angiogenetic process rises simultaneously with the risk of metastasis. This study shows a significant correlation between the density of vessels and the evolution of the uterine cervix carcinomas, the appearance of recurrences and metastasis. The quantification of the angiogenesis is an indicator with an high degree of precision, with is used for the detection of the aggressiveness and malignancy of the uterine cervix tumors