Introduction: Infertility is a common complication present in 10-15% of the population. It causes serious problems for the family. There are different methods for evaluation and treatment of infertility. One of the routine tests is hysterosalpingography that was first used in1922 and with changes in types of contrast media and its techniques, it is the primary test for simultaneous evaluation of tube, uterus body and cervix. Methods: This descriptive clinical outcome study was carried out on the base of a case series study. The study was performed on 117 patients who referred for HSG procedure and were followed for 2 years for detection of pregnancy. Data was analyzed by SPSS.14, and statistical tests included student’s t-test, chi-square and Fisher exact test. Results: The mean age of patients was 26±4.7 years. Duration of infertility was 6 years. Of the total, 98(83.8%) cases had one or both patent tubes on HSG. They didn’t have any established causes of infertility after scrutiny of other findings and 51(43.6%) cases became pregnant during 2 years (CI=95%,34.6-52.6%). Notable point was that 86.3% of pregnancies occurred in the first 6-months after HSG procedure. Conclusion: HSG plays a significant role in infertility diagnosis and treatment in spite of the new techniques and methods for infertility diagnosis and treatment; so follow up and control of patient for 6 months after HSG is recommended. If HSG fails, other procedures such as laparoscopy can be done