Thermoradiotheraphy of cancer: an effective approach

Abstract

Hyperthermia (HT) means using controlled temperatures of 40-45°C for cancer treatment. HT is applied with differentmethods e.g. superficial-HT, locoregional deep-HT, interstitial-HT, intracavity-HT, and whole body-HT. HT can apply indifferent tumor sites such as breast cancer, melanoma, head and neck, cervix cancer, and glioblastoma. The Literature suggests that addition of HT to radiotherapy, chemotherapy, or both, will result better tumor response rate, local control, and survival rate; without increasing toxicity. HT can also improve palliative effects in patient. In recent years, due to substantial technical improvements made in achieving selected increaseof temperatures in superficial and deep-seated tumors,thermometry, and treatment planning; HT is becoming moreclinically accepted in Europe and the USA. HT, as an adjunctcancer treatment modality, is certainly a promising approach;however, it is not well known yet worldwide. Therefore, itseems there is need to know more about that. The purpose of this review is to provide an overview on the application of HT combined with conventional cancer treatment modalities,mainly radiotherapy. The article also introduces mechanism of HT, heating delivery modes, thermometry, and it summarizes results of randomized trials from Western research groups