Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health
Abstract
"This Skin Notation Profile presents (1) a brief summary of technical data associated with skin contact with BE and (2) the rationale behind the hazard-specific skin notation (SK) assignment for BE. The SK assignment is based on the scientific rationale and logic outlined in the Current Intelligence Bulletin (CIB) 61: A Strategy for Assigning New NIOSH Skin Notations [NIOSH 2009]. The summarized information and health hazard assessment are limited to an evaluation of the potential health effects of dermal exposure to BE. A literature search was conducted through July 2010 to identify information on BE, including but not limited to data relating to its toxicokinetics, acute toxicity, repeated-dose systemic toxicity, carcinogenicity, biological system/function-specific effects (including reproductive and developmental effects and immunotoxicity), irritation, and sensitization. Information was considered from studies of humans, animals, or appropriate modeling systems that are relevant to assessing the effects of dermal exposure to BE. BE is potentially capable of causing multiple toxic effects following skin contact. A critical review of available data has resulted in the following SK assignment for BE: SK: SYS-DIR (IRR). Table 1 provides an overview of the critical effects and data used to develop the SK assignment for BE." - NIOSHTIC-2Foreword -- Abbreviations -- Glossary -- Acknowledgments -- 1. Introduction -- 1.1. General Substance Information -- 1.2. Purpose -- 1.3. Overview of SK Assignment for BE -- 2. Systemic Toxicity from Skin Exposure (SK: SYS) -- 3. Direct Effects on Skin (SK: DIR) -- 4 Immune-mediated Responses (SK: SEN) -- 5. Summary -- References -- Appendix: Calculation of the SI ratio for BE -- Overview -- Calculation -- Appendix: References"This document was developed by the Education and Information Division, Paul Schulte, Ph.D., Director. G. Scott Dotson, Ph.D. was the project officer for this document. Other NIOSH personnel, in particular Clayton B. Hymer, Ph.D., Charles L. Geraci, Ph.D., Thomas J. Lentz, Ph.D., Richard Niemeier, Ph.D., and Paul Siegel, Ph.D., contributed to its development by providing technical reviews and comments. The basis for this document was a report contracted by NIOSH and prepared by Bernard Gadagbui, Ph.D., and Andrew Maier, Ph.D. (Toxicology Excellence for Risk Assessment [TERA])." - p. ix"April 2011."Includes bibliographical references (p. 7-9).Also available via the World Wide Web as Acrobat .pdf file (729 kB, 28 p.)
