Grid polymeric scaffolds with polypeptide gel filling as patches for infarcted tissue regeneration

Abstract

© 2013 IEEE. Personal use of this material is permitted. Permissíon from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertisíng or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works.[EN] Scaffolds of poly(ethyl acrylate) (PEA) with interconnected cylindrical orthogonal pores filled with a self-assembling peptide (SAP) gel are here proposed as patches for infarcted tissue regeneration. These combined systems aim to support cell therapy and meet further requirements posed by the application: the three-dimensional architecture of the elastomeric scaffold is expected to lodge the cells of interest in the damaged zone avoiding their death or migration, and at the same time conduct cell behavior and give mechanical support if necessary; the ECM-like polypeptide gel provides a cell-friendly aqueous microenvironment, facilitates diffusion of nutrients and cell wastes and is expected to improve the distribution and viability of the seeded cells within the pores and stimulate angiogenesis.Research supported by the European Comission through the RECATABI FP7 NMP3-SL-2009-229239 project and the spanish Ministerio de Ciencia e Innovación through the MAT2011-28791-C03-02 and -03 projects.Vallés Lluch, A.; Arnal Pastor, MP.; Martínez-Ramos, C.; Vilariño, G.; Vikingsson, L.; Monleón Pradas, M. (2013). Grid polymeric scaffolds with polypeptide gel filling as patches for infarcted tissue regeneration. Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society. 6961-6964. https://doi.org/10.1109/EMBC.2013.6611159S6961696