Feasibility, safety and efficacy of transauricular vagus nerve stimulation in a cohort of patients with disorders of consciousness

Abstract

This work was supported by grant from the European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement no. 778234- DoCMA project and by Conselleria de Educacion, Investigacion, Cultura y Deporte of Generalitat Valenciana (SEJI/2019/017) and Vicerrectorado de Investigacion, Innovacion y Transferencia of Universitat Politecnica de Valencia (PAID-06-18).Noé, E.; Ferri, J.; Colomer, C.; Moliner, B.; O'valle, M.; Ugart, P.; Rodríguez, C.... (2020). Feasibility, safety and efficacy of transauricular vagus nerve stimulation in a cohort of patients with disorders of consciousness. Brain Stimulation. 13(2):427-429. https://doi.org/10.1016/j.brs.2019.12.005S427429132Thibaut, A., Schiff, N., Giacino, J., Laureys, S., & Gosseries, O. (2019). Therapeutic interventions in patients with prolonged disorders of consciousness. The Lancet Neurology, 18(6), 600-614. doi:10.1016/s1474-4422(19)30031-6Engineer, N. D., Kimberley, T. J., Prudente, C. N., Dawson, J., Tarver, W. B., & Hays, S. A. (2019). Targeted Vagus Nerve Stimulation for Rehabilitation After Stroke. Frontiers in Neuroscience, 13. doi:10.3389/fnins.2019.00280Corazzol, M., Lio, G., Lefevre, A., Deiana, G., Tell, L., André-Obadia, N., … Sirigu, A. (2017). Restoring consciousness with vagus nerve stimulation. Current Biology, 27(18), R994-R996. doi:10.1016/j.cub.2017.07.060Yu, Y., Yang, Y., Wang, L., Fang, J., Chen, Y., He, J., & Rong, P. (2017). Transcutaneous auricular vagus nerve stimulation in disorders of consciousness monitored by fMRI: The first case report. Brain Stimulation, 10(2), 328-330. doi:10.1016/j.brs.2016.12.004Thibaut, A., Di Perri, C., Chatelle, C., Bruno, M.-A., Bahri, M. A., Wannez, S., … Laureys, S. (2015). Clinical Response to tDCS Depends on Residual Brain Metabolism and Grey Matter Integrity in Patients With Minimally Conscious State. Brain Stimulation, 8(6), 1116-1123. doi:10.1016/j.brs.2015.07.024Keute, M., Ruhnau, P., Heinze, H.-J., & Zaehle, T. (2018). Behavioral and electrophysiological evidence for GABAergic modulation through transcutaneous vagus nerve stimulation. Clinical Neurophysiology, 129(9), 1789-1795. doi:10.1016/j.clinph.2018.05.026Kleim, J. A., & Jones, T. A. (2008). Principles of Experience-Dependent Neural Plasticity: Implications for Rehabilitation After Brain Damage. Journal of Speech, Language, and Hearing Research, 51(1). doi:10.1044/1092-4388(2008/018)Thibaut, A., Wannez, S., Donneau, A.-F., Chatelle, C., Gosseries, O., Bruno, M.-A., & Laureys, S. (2017). Controlled clinical trial of repeated prefrontal tDCS in patients with chronic minimally conscious state. Brain Injury, 31(4), 466-474. doi:10.1080/02699052.2016.1274776Van Erp, W. S., Aben, A. M. L., Lavrijsen, J. C. M., Vos, P. E., Laureys, S., & Koopmans, R. T. C. M. (2019). Unexpected emergence from the vegetative state: delayed discovery rather than late recovery of consciousness. Journal of Neurology, 266(12), 3144-3149. doi:10.1007/s00415-019-09542-3Thibaut, A., Chennu, S., Chatelle, C., Martens, G., Annen, J., Cassol, H., & Laureys, S. (2018). Theta network centrality correlates with tDCS response in disorders of consciousness. Brain Stimulation, 11(6), 1407-1409. doi:10.1016/j.brs.2018.09.00