« Nous devons une profonde gratitude à Philippe Suchard, à Carl Russ-Suchard et surtout à la multitude de collaborateurs qui ont consacré une grande partie de leur vie à cette entreprise. Grâce à eux, Suchard est aujourd’hui l’une des plus importantes entreprises suisses du secteur ». En mai 1976, l’éditorial du magazine de l’entreprise Suchard Nous et notre travail, publié dans un numéro spécial à l’occasion du 150e anniversaire de la fondation de l’usine de Serrières, remercie la multitude de travailleurs et travailleuses de diverses nationalités. Nous nous trouvons à la fin des Trente Glorieuses2 et ce texte semble anticiper ce que va traverser une entreprise ayant connu nombre de moments difficiles

Borja Martinez-Tellez

Francisco J. Amaro-Gahete

Francisco M. Acosta

Guillermo Sanchez-Delgado

Jonatan R. Ruiz

Jose M. Llamas-Elvira

Juan M. A. Alcantara

Yolanda Garcia-Rivero

Frontiers in Physiology

Cold induced thermogenesis (CIT) in humans results mainly from the combination of both brown adipose tissue (BAT) and skeletal muscle thermogenic activity. The relative contribution of both tissues to CIT and to cold induced nutrient oxidation rates (CI-NUTox) remains, however, to be elucidated. We investigated the association of BAT and skeletal muscle activity after a personalized cold exposure with CIT and CI-NUTox in 57 healthy adults (23.0 ± 2.4 years old; 25.1 ± 4.6 kg/m2; 35 women). BAT and skeletal muscle (paracervical, sternocleidomastoid, scalene, longus colli, trapezius, parathoracic, supraspinatus, subscapular, deltoid, pectoralis major, and triceps brachii) metabolic activity were assessed by means of a 18Fluorodeoxyglucose positron emission tomography-computed tomography scan preceded by a personalized cold exposure. The cold exposure consisted in remaining in a mild cold room for 2 h at 19.5–20°C wearing a water perfused cooling vest set at 3.8°C above the individual shivering threshold. On a separate day, we estimated CIT and CI-NUTox by indirect calorimetry under fasting conditions for 1 h of personalized cold exposure. There was no association of BAT volume or activity with CIT or CI-NUTox (all P &gt; 0.2). Similarly, the skeletal muscle metabolic activity was not associated either with CIT or CI-NUTox (all P &gt; 0.2). The results persisted after controlling for sex, the time of the day, and the date when CIT was assessed. Our results suggest that human BAT activity and skeletal muscle 18F-FDG activity are not associated to CIT in young healthy adults. Inherent limitations of the available radiotracers for BAT detection and muscle activity quantification may explain why we failed to detect a physiologically plausible association

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Brown Adipose Tissue and Skeletal Muscle 18F-FDG Activity After a Personalized Cold Exposure Is Not Associated With Cold-Induced Thermogenesis and Nutrient Oxidation Rates in Young Healthy Adults

Cold induced thermogenesis (CIT) in humans results mainly from the combination
of both brown adipose tissue (BAT) and skeletal muscle thermogenic activity. The
relative contribution of both tissues to CIT and to cold induced nutrient oxidation
rates (CI-NUTox) remains, however, to be elucidated. We investigated the association
of BAT and skeletal muscle activity after a personalized cold exposure with CIT
and CI-NUTox in 57 healthy adults (23.0   2.4 years old; 25.1   4.6 kg/m2; 35
women). BAT and skeletal muscle (paracervical, sternocleidomastoid, scalene, longus
colli, trapezius, parathoracic, supraspinatus, subscapular, deltoid, pectoralis major, and
triceps brachii) metabolic activity were assessed by means of a 18Fluorodeoxyglucose
positron emission tomography-computed tomography scan preceded by a personalized
cold exposure. The cold exposure consisted in remaining in a mild cold room for 2 h at
19.5–20 C wearing a water perfused cooling vest set at 3.8 C above the individual
shivering threshold. On a separate day, we estimated CIT and CI-NUTox by indirect
calorimetry under fasting conditions for 1 h of personalized cold exposure. There was
no association of BAT volume or activity with CIT or CI-NUTox (all P > 0.2).The study was supported by the Spanish Ministry of Economy
and Competitiveness (PTA 12264-I), Fondo de Investigación
Sanitaria del Instituto de Salud Carlos III (PI13/01393), and
Retos de la Sociedad (DEP2016-79512-R), Fondos Estructurale

Sánchez-Delgado, Guillermo

Martínez Téllez, Borja Manuel

García Rivero, Yolanda

Acosta Manzano, Francisco Miguel

Amaro Gahete, Francisco José

Alcantara, Juan M.A.

Llamas Elvira, José Manuel

Ruiz Ruiz, Jonatan

Repositorio Institucional Universidad de Granada

English

Cold induced thermogenesis (CIT) in humans results mainly from the combination of both brown adipose tissue (BAT) and skeletal muscle thermogenic activity. The relative contribution of both tissues to CIT and to cold induced nutrient oxidation rates (CI-NUTox) remains, however, to be elucidated. We investigated the association of BAT and skeletal muscle activity after a personalized cold exposure with CIT and CI-NUTox in 57 healthy adults (23.0 ± 2.4 years old; 25.1 ± 4.6 kg/m2; 35 women). BAT and skeletal muscle (paracervical, sternocleidomastoid, scalene, longus colli, trapezius, parathoracic, supraspinatus, subscapular, deltoid, pectoralis major, and triceps brachii) metabolic activity were assessed by means of a 18Fluorodeoxyglucose positron emission tomography-computed tomography scan preceded by a personalized cold exposure. The cold exposure consisted in remaining in a mild cold room for 2 h at 19.5-20°C wearing a water perfused cooling vest set at 3.8°C above the individual shivering threshold. On a separate day, we estimated CIT and CI-NUTox by indirect calorimetry under fasting conditions for 1 h of personalized cold exposure. There was no association of BAT volume or activity with CIT or CI-NUTox (all P > 0.2). Similarly, the skeletal muscle metabolic activity was not associated either with CIT or CI-NUTox (all P > 0.2). The results persisted after controlling for sex, the time of the day, and the date when CIT was assessed. Our results suggest that human BAT activity and skeletal muscle 18F-FDG activity are not associated to CIT in young healthy adults. Inherent limitations of the available radiotracers for BAT detection and muscle activity quantification may explain why we failed to detect a physiologically plausible association

Sanchez-Delgado, Guillermo

Martinez-Tellez, Borja

Garcia-Rivero, Yolanda

Alcantara, Juan M A

Acosta, Francisco M

Amaro-Gahete, Francisco J

Llamas-Elvira, Jose M

Ruiz, Jonatan R

Fondo Bibliográfico Digital Institucional

Brown Adipose Tissue and Skeletal Muscle 18F-FDG Activity After a Personalized Cold Exposure Is Not Associated With Cold-Induced Thermogenesis and Nutrient Oxidation Rates in Young Healthy Adults.

Diabetes mellitus: pathophysiological changes and therap

Sanchez-Delgado, G.

Martinez-Tellez, B.

Garcia-Rivero, Y.

Alcantara, J.M.A.

Acosta, F.M.

Amaro-Gahete, F.J.

Llamas-Elvira, J.M.

Ruiz, J.R.

Leiden University Scholary Publications

Brown Adipose Tissue and Skeletal Muscle F-18-FDG Activity After a Personalized Cold Exposure Is Not Associated With Cold-Induced Thermogenesis and Nutrient Oxidation Rates in Young Healthy Adults

Frontiers - Publisher Connector

Cold induced thermogenesis (CIT) in humans results mainly from the combination of both brown adipose tissue (BAT) and skeletal muscle thermogenic activity. The relative contribution of both tissues to CIT and to cold induced nutrient oxidation rates (CI-NUTox) remains, however, to be elucidated. We investigated the association of BAT and skeletal muscle activity after a personalized cold exposure with CIT and CI-NUTox in 57 healthy adults (23.0 ± 2.4 years old; 25.1 ± 4.6 kg/m2; 35 women). BAT and skeletal muscle (paracervical, sternocleidomastoid, scalene, longus colli, trapezius, parathoracic, supraspinatus, subscapular, deltoid, pectoralis major, and triceps brachii) metabolic activity were assessed by means of a 18Fluorodeoxyglucose positron emission tomography-computed tomography scan preceded by a personalized cold exposure. The cold exposure consisted in remaining in a mild cold room for 2 h at 19.5–20°C wearing a water perfused cooling vest set at 3.8°C above the individual shivering threshold. On a separate day, we estimated CIT and CI-NUTox by indirect calorimetry under fasting conditions for 1 h of personalized cold exposure. There was no association of BAT volume or activity with CIT or CI-NUTox (all P > 0.2). Similarly, the skeletal muscle metabolic activity was not associated either with CIT or CI-NUTox (all P > 0.2). The results persisted after controlling for sex, the time of the day, and the date when CIT was assessed. Our results suggest that human BAT activity and skeletal muscle 18F-FDG activity are not associated to CIT in young healthy adults. Inherent limitations of the available radiotracers for BAT detection and muscle activity quantification may explain why we failed to detect a physiologically plausible association.</p

Guillermo Sanchez-Delgado (5180933)

Borja Martinez-Tellez (5180942)

Yolanda Garcia-Rivero (5980121)

Juan M. A. Alcantara (5180939)

Francisco M. Acosta (5141756)

Francisco J. Amaro-Gahete (5389724)

Jose M. Llamas-Elvira (5980124)

Jonatan R. Ruiz (142368)

FigShare

Image_1_Brown Adipose Tissue and Skeletal Muscle 18F-FDG Activity After a Personalized Cold Exposure Is Not Associated With Cold-Induced Thermogenesis and Nutrient Oxidation Rates in Young Healthy Adults.tif

Institutional Repository of the University of Granada

https://www.frontiersin.org/articles/10.3389/fphys.2018.01577/pdf