The objectives of this study were to: (1) check whether it is feasible to find changes in inflammation biomarkers
through an mHealth strategy app as a delivery mechanism of an intervention to monitor energy balance; and (2) discover potential
predictors of change of these markers in breast cancer survivors (BCSs). Analyzing changes in inflammatory biomarker concentrations after using the mHealth app, differences between
preassessment CRP (4899.04 pg/ml; SD 1085.25) and IL-6 (87.15 pg/ml; SD 33.59) and postassessment CRP (4221.24 pg/ml;
SD 911.55) and IL-6 (60.53 pg/ml; SD 36.31) showed a significant decrease in both markers, with a mean difference of –635.25
pg/ml (95% CI –935.65 to –334.85; P<.001) in CRP and –26.61 pg/ml (95% CI –42.51 to –10.71; P=.002) in IL-6. Stepwise
regression analyses revealed that changes in global quality of life, as well as uMARS score and hormonal therapy, were possible predictors of change in CRP concentration after using the mHealth app. In the same way, the type of tumor removal surgery
conducted, as well as changes in weight and pain score, were possible predictors of change in IL-6 concentration after using the
app. In conclusion, through the results of this study, we hypothesize that there is a possible association between an
mHealth energy balance monitoring strategy and biological changes in BCSs. These changes could be explained by different
biopsychosocial parameters, such as the use of the application itself, quality of life, pain, type of tumor removal surgery, hormonal
treatment or obesity.The study was funded by the Spanish Ministry of Economy and Competitiveness (Plan Estatal de I+D+I 2013-2016), Fondo de
Investigación Sanitaria del Instituto de Salud Carlos III (PI14/01627), Fondos Estructurales de la Unión Europea (FEDER), and
by the Spanish Ministry of Education (FPU14/01069 and FPU17/00939)