This study developed an advance understanding of the mechanisms of hydraulic fracture initiation, propagation, and natural fractures interaction based-on thorough investigation of effects of various parameters associated with hydraulic and natural fractures through numerical modelling, simulation and laboratory experiments. Thesis progressively demonstrates different steps of the development of numerical modelling, simulation and experimental validation. Factors influencing the initiation and propagation of hydraulic fracture, and natural fractures interactions are thoroughly discussed based upon comprehensive sensitivity studies