This work was possible thanks to the funding that Junta de Andaluca awarded to the research group CTS454. J Arag?onVela was awarded a Formaci?on de Profesorado Universitario (FPU) fellowship from the Ministry of Education, Culture and Sports of the Spanish Government (AP20121867) . This paper was part of Jer?onimo Arag?on Vela's PhD thesis, performed within the "Nutrition and Food Sciences Program" at the University of Granada, Spain. We thank Nutraceutical Trans-lations for English language editing of this manuscript.Background: The purpose of this study was to investigate the inflammatory response, lipid
peroxidation and muscle damage in men and women athletes subjected to an acute
resistance exercise.
Methods: Twenty college athletes (10 men and 10 women) performed a half-squat exercise
consisting of five incremental intensities: 20%, 40%, 60%, 80% and 100% of the onerepetition
maximum. Blood samples were collected at rest, 15 min and 24 h post-test.
The concentration of lipid peroxidation markers and the activities of a skeletal muscle
damage marker and a cardiac muscle damage marker were determined in serum. Serum aactin
was measured as a marker of sarcomere damage. Serum levels of interleukin-6,
interleukin-10, and tumor necrosis factor alpha were determined to assess the inflammatory
response.
Results: Interleukin-6 levels were higher at 24 h post-test than at rest and 15 min post-test
in men (p < 0.05). Moreover, men showed significantly higher hydroperoxide levels in
response to resistance exercise at 24 h post-test than at 15 min post-test (p < 0.05). No
differences were found in muscle damage parameters regardless of sex or the time point of
the test. No differences regarding the studied variables were found when comparing
among different time points in women.
Conclusion: Our results show a larger influence of half-squat exercises on the release of IL6
and on lipid peroxidation in men than in women at equivalent workloads.Junta de Andalucia CTS-454Formacion de Profesorado Universitario (FPU) fellowship from the Ministry of Education, Culture and Sports of the Spanish Government AP2012-186