Research advances on cytosine deaminase APOBEC1

Abstract

In order to fully understand the mechanisms of Apolipoprotein B mRNA(ApoB mRNA)editing enzyme catalytic polypeptide-1(APOBEC1), this review introduced the amino acid and nucleic acid sequences of APOBEC1 and ApoB mRNA, summarized and mapped the binding models of APOBEC1 with different cofactors to explain the molecular mechanism of APOBEC1 catalyzing the deamination of the 6666 C of ApoB mRNA(C6666). The researches of rodent APOBEC1 inhibiting multiple retroviruses were exemplified here, and the related mechanisms of rabbit APOBEC1 binding to human immunodeficiency virus type 1(HIV-1)and editing the viral genome were discussed.This review also introduced APOBEC1 regulating the expression of cytokines related to cancers and other diseases by deamination editing or combining with AU-rich element (ARE)of RNAs