The aim of the study is to summarize our own research experience on interaction of respiratory system and blood circulation in patients with chronic obstructive lung disease (COLD). The main directions of the study include screening of combination of COLD and systemic arterial hypertension (SAH); pathogenesis of SAH and COLD; screening of the first dose effects of various antihypertensive drugs subject to their influence on respiratory function and a gas homeostasis. It has been revealed that prevalence of SAH in patients with COLD significantly exceeds the population rate. SAH is characterized by daily stability of arterial blood pressure, low night blood pressure reduction and high loading pressure in patients with COLD. Antihypertensive efficiency of the first doses of anthenol, indapamide, perindopril and telmisartan are comparable on obligation and blood pressure reduction rate. The first dose of the receptor antagonists to angiotensin II telmisartan provides a significant gain of peak expiratory flow, similar, but weaker effect is observed in response to indapamide intake
