Lymphogranulomatosis (Hodgkin lymphoma) is a timorous disease of the lymphatic system. Clinical manifestations may be polymorph with isolated or multiple organ and body system invasions which cause trouble while diagnosing and administrating specific therapy. Nervous system invasion occurs following neurogenesis compression or their infiltration from lymphogranulomatosis nodes, primary lymphoma in CNS, paraneoplastic reaction. Clinical findings from the lymphogranulomatosis onset as neurological evidences are demonstrated: myelopathy with upper thoracic segments invasions and lower paraplegia development. We performed diagnostic search, laparotomy with biopsy of retroperitoneal para-aortic lymph nodes, histopathologic examination of lymph nodes confirmed diagnosis of lymphogranulomatosis. We performed specific treatment in the department of hematology and observed complete regress of neurological symptoms
