An autopsy case of hepatocellular carcinoma combined with hemochromatosis and hepatic cirrhosis were studied with iron accumulation and hepatitis B virus. Iron accumulation was confirmed by Prussian blue reaction. A positive reaction for hepatitis B surface antigen and hepatitis B core antigen were investigated by immunoperoxidase methods. Hepatocellular carcinoma with hepatitis B core antigen is accompanied by iron accumulation. This suggests that hepatitis B core antigen produces degeneration or collapse of genes of hepatocellular carcinoma resulting in iron metabolism disorder
