This work is about statistical genetics, an interdisciplinary topic between
Statistical Physics and Population Biology. Our focus is on the phase of
Quasi-Linkage Equilibrium (QLE) which has many similarities to equilibrium
statistical mechanics, and how the stability of that phase is lost. The QLE
phenomenon was discovered by Motoo Kimura and was extended and generalized to
the global genome scale by Neher & Shraiman (2011). What we will refer to as
the Kimura-Neher-Shraiman (KNS) theory describes a population evolving due to
the mutations, recombination, genetic drift, natural selection (pairwise
epistatic fitness). The main conclusion of KNS is that QLE phase exists at
sufficiently high recombination rate (r) with respect to the variability in
selection strength (fitness). Combining these results with the techniques of
the Direct Coupling Analysis (DCA) we show that in QLE epistatic fitness can be
inferred from the knowledge of the (dynamical) distribution of genotypes in a
population. Extending upon our earlier work Zeng & Aurell (2020) here we
present an extension to high mutation and recombination rate. We further
consider evolution of a population at higher selection strength with respect to
recombination and mutation parameters (r and μ). We identify a new
bi-stable phase which we call the Non-Random Coexistence (NRC) phase where
genomic mutations persist in the population without either fixating or
disappearing. We also identify an intermediate region in the parameter space
where a finite population jumps stochastically between QLE-like state and
NRC-like behaviour. The existence of NRC-phase demonstrates that even if
statistical genetics at high recombination closely mirrors equilibrium
statistical physics, a more apt analogy is non-equilibrium statistical physics
with broken detailed balance, where self-sustained dynamical phenomena are
ubiquitous