Pathogenesis of the Lesions of Glomerulus and Renal Arteriole in Experimental Hypertension

Abstract

Rats with adrenal regeneration hypertension were divided by the degree of blood pressure, and the changes in renal glomerulus were studied mainly with electron microscope. The increase in mesangial basement membrane like material and in the mesangial cells occurred as the early changes in the glomerulus. The mesangial basement membrane like material was extremely increased with an increase in blood pressure or with time. In some cases, fibrinoid necrosis appeared. It was considered that the increased mesangial basement membrane like material was produced anew, since the silver granules which were previously labeled were not deposited into them. Fibrinoid necrosis was considered to arise mainly from the interruption of the blood circulation, such as collapse of the capillary loop and platelet thrombi, and hyperpermeability. The findings of argyrosis could be ruled out in this study, since there were no findings which were suspected to show the renal lesions caused by the oral administration of a silver nitrate solution used as a label