Biomolecular markers and prediction of pre-eclampsia : A Narrative Review

Abstract

Pre-eclampsia (PE) is a pathology specifically related to pregnancy ; it can lead to intense maternal and fetal morbidity and mortality. To date, various and multiple models for predicting PE have been developed. This review aimed at providing an overview of research on biomarkers that predict PE and comparing them. An exhaustive search of related articles published between 01/01/2018 and 30/12/2019, using pre-defined criteria, was conducted via PubMed and Science Direct databases. A total of 21 studies including a total of 42 models for predicting PE, conducted on 111,244 women, were selected. The gestational age at the time of the prediction ranged from 35 to 37 week. Different biomarkers were identified (PlGF and sFlt-1, PLGF, IL-27, mir, rs, AU, PNN/lympho) ; the latter had considerable, significant predictive values (generally at a significance degree <0.05), and may be considered as promising predictors.