Leaves of mulberry (Morus alba L.) is one of the medicinal plants that contains antihyperglycemic and antioxidant compounds. These compounds are known as agent that could decrease the high blood glucose levels and improve organ damage caused by free radicals in hyperglycemic conditions. This study aimed to determine the effect of mulberry leaves infusion on reproduction status of chronic diabetes model. This research was an experimental study using completely randomized design (CRD) with 6 treatments and 4 replications. The treatments were C+ (positive control), C- (negative control), T1 (400 mg/kgbw), P2 (600 mg/kgbw), P3 (800 mg/kgbw) and P4 (1000 mg/kgbw). 24 of wistar rats, male, 1 month old, and 70-100 grams of body weight were used as animal models. Data observed in this study include the number of germ cells (spermatogonia, primary spermatocytes, secondary spermatocytes, spermatids and spermatozoa), sertoli cells, seminiferous tubules diameter, leidig cells, testes weight and testosteron levels. Data were analyzed with One Way Anova, and then followed by DMRT (1%) analysis if there is a significant differences between treatments. The results showed that the infusion of mulberry leaves increased the number of germinal cells, sertoli cells, diameter of seminiferous tubules, leidig cell, testis weight, and testosteron levels of chronic diabetic model. The optimum infusion dose of mulberry leaves was T4 (1000 mg/kgbw)
