Background: the updating of the available specialized information on Sweet's syndrome, a rare disease, may result in avoiding diagnosis delays, incorrect treatments and complications that would affect patients, and may even cause death.Objective: to describe, in the form of a review article, different aspects related to Sweet’s syndrome, a skin condition included in the group of rare diseases.Methods: an updated bibliographic review was carried out, using the resources available in the Infomed network, specifically: PubMed, SciELO and Ebsco, through the databases: Medline, Academic Search Premier, MedicLatina, as well as Cumed, Lilacs and Scopus.Results: contents related to epidemiology, clinical characteristics, histology, physiology, variants, complications, differential diagnosis, treatment and prognosis of Sweet’s syndrome were collected. This syndrome may be associated with infectious, systemic, immunological or malignant neoplastic processes. It usually presents a high level of clinical complexity that makes it difficult to be recognized and diagnosed. In general, patients improve with the appropriate treatment if it is performed at the proper time.Conclusions: the review updated the information about Sweet's syndrome, a skin disease with a marked clinical expression and complex to be diagnosed.</p
