Background and Aims: Sexual dysfunction in women is very common and is one of the important indicators in the marital satisfaction and family strengthening. This study aimed to determine some predictive factors of women's sexual function. Materials and Methods: In this cross-sectional study, 200 married women referred to health centers in Tehran city were selected through convenience sampling. The research tools included a valid and reliable questionnaire including demographic information and women's sexual function index. Data were analyzed using SPSS 20 software and independent t-test, one-way ANOVA, Spearman and Pearson correlations and linear regression. Ethical standards such as confidentiality of information were observed in all stages of research. Results: The mean score of sexual function was 21.14±4.35 (from 36). In this study 22% (n=44) of respondents reported sexual desire disorder, 32.5% (n=65) arousal disorder, 27.5% (n=57) sexual dysfunction, 22% (n=44) orgasmic disorder, 29% (n=58) sexual dissatisfaction and 20.5% (n=41) sexual pain disorder. There was a significant and inverse correlation between spouse's age, duration of marriage, date of last delivery and sexual function. In the multiple regression model, marital status (B=0.148, P=0.033), spouse interest (B=0.0286, P=0.001) and spouse age (B=0.207, P= 0.001) were significant predictors of sexual function. Conclusion: According to the results, women who describe a happier life and are interested in their spouse as well as are younger than their spouse reported a more desirable sexual performance. The results can be used to implement psychological and cultural programs in the community to reduce couples' problems. Keywords: Sexual function, Female, Sexual satisfactio