Background and Aims: Breast cancer is the most common type of cancer diseases among women. The survival rate of breast cancer patients is long and, as a result, patients are greatly affected by cancer, its complications and consequences.Materials and Methods: The research design was descriptive – cross sectional. About 150 patients (women) with breast cancer were candidate for chemotherapy referred to the ward of Oncology in Shohada Tajrish and Taleghani Hospitals, both under the auspicious of Shahid Beheshti University of Medical science, 2017. The standard Quality of life Questionnaire (EROTC QLQ_C30) and its breastcancer supplementary measure (QLQ-BR 23) Questionnaire developed by the European Organization for Research and treatment of cancer were respectively used to measure the quality of life and for demography, within one stage. Finally, the data was analyzed using SPSS16 statistical software through ANOVA and Pearson tests. All ethical issues were considered throughout the study.Results: The average age of women whom surveyed was 47.81±8.21, which 74.7 percent of them were married. The average score of the global health status of respondents undergone the survey was 538818.20±. Among the functional scores, the highest score was related to cognitive indexes 68.77± 30.30. Economic difficulties showed the highest score of 69.11 27.33± among symptom scales. Physical,emotional and cognitive functioning, and also the disease symptoms such as fatigue, nausea and vomiting, pain, dyspnoea, insomnia, constipation and economic difficulties were among the variables demonstrating significance relationship with quality of life in Univariate Analysis.Conclusion: The results of this study show the inappropriate conditions regarding the quality of life in some general and specific symptom scales of the patients under the survey. Therefore, the importance of paying more attention to this matter and designing of suitable actions for enhancing the quality of theirlife is expected. Keyword: Breast cancer, Quality of life, Wome