AbstractBackground and aimSymptoms of Multiple Sclerosis (MS) are unpredictable; they vary from person to person, and fromtime to time in the same individual. Research conducted in Iran, didn't focus specifically onthe health status of MS. Therefore, we undertook this study on physical health status in MS patients.Materials and MethodsThis is a descriptive cross-sectional study on 119 MS patients, recruited through conveniencesampling. Data were collected using the physical section of the "Multiple Sclerosis Quality of LifeInventory (MSQLI)", with 78 items and 0.93 Cronbach's coefficient that translated to Persian andadapted to Iranian culture by researchers.FindingsThe physical health status was moderate in 49.6%. The lowest mean score percent was for physicalcomponent 41.06(12.9) and the highest mean score percent was for Impact of visual impairment87.05(16.1). Physical components indicated a significant positive correlation with fatigue impact,pain effect and bladder control. 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