sensitivity C-reactive protein (CRP), tumor necrosis factor (TNF-), and interleukin-6 (IL-6) have been associated with an increased risk of diabetes. METHODS: To examine the roles of genetic variation in the genes encoding CRP, TNF- , and IL-6 in the de-velopment of diabetes, we conducted a prospective case–control study nested within the Women’s Health Initiative Observational Study. We followed 82 069 postmenopausal women (50–79 years of age) with no history of diabetes for incident diabetes for a mean follow-up of 5.5 years. We identified 1584 cases and matched them with 2198 controls with respect to age, ethnicity, clinical center, time of blood draw, and length of follow-up. We genotyped 13 haplotype-tagging single-nucleotide polymorphisms (tSNPs
