Introduction: Different molecular approaches have contributed to find various response of skin to external and internal tensions such as laser irradiation and many important mediators of skin disease have been identified through these approaches. However different essential signals of skin biomarker pathways and proteins partially detected or completely unknown. In the present study impact of proteomics in the evaluation of laser therapy of skin is investigated.Methods: Keywords of “Proteomics”, Laser therapy”, “Skin”, and “Skin disease” searched in Google Scholar, Scopus and PubMed search engines. After screening, 53 documents were included in the study.Results: Global assessments revealed that different proteins in different signaling pathways of skin metabolism in terms of health or illness after laser therapy are expressed differentially. Results indicated that application of proteomics is a useful method to promote the results of laser interventions.Conclusion: This kind of researches deals with practical proteomics of skin and could supply an essential skip to understand skin diseases to develop more suitable therapeutic achievements in laser application
