Optimization of the synthesis of Copper(I) phenylacetylide

Abstract

Copper(l) phenylacetylide is a chemical compound that plays an important role in medical chemistry, pharmaceutical manufacturing, drug development, and general chemical synthesis (1-4). It has a characteristic yellow color in the solid state, making it easy to identify. Copper(l) phenylacetylide is produced from the reaction of basic copper(l) oxide CU₂O, with the weak acid phenylacetylene in ethanol, with a sulfuric acid catalyst. Available methods for making these compound are difficult, time-consuming and require environmentally hazardous solvents. We have found a new way to synthesize Copper(l) phenylacetylide by a simple, quick and "green" synthesis. Our method offers multiple advantages, since no reducing agent is needed and air-free conditions are required during filtration. The starting materials are all available commercially a good price and the solvent used, 95% ethanol, is environmentally friendly