Studying Animal Model For Diabetes Mellitus And The Hypoglycemic Effects Of Coptis Teeta Wall On Animal Models

Abstract

Coptis teeta Wall is known as Hoang Lien, a precious herb and found mostly on Hoang Lien Son mountains, Vietnam. Its rhizomes, contain many chemical compounds have anti-virus, anti-inflammatory, hypoglycemic, anti-fungal, anti-pertussis and antihypertensive effects, are used as drugs.In this study, we studied the hypoglycemic effect of the Hoang Lien root extracted by ethanol in alloxan induced diabetic mice. According to the results, the blood glucose levels of the diabetic mice were reduced from 500 mg/dl to less than 200 mg/dl after 20 days administration at the dose of 150, 200 and 250 mg/kg. Besides, the physiological indicators of mice are stable. Thus, it was found that the extract of Hoang Lien roots possesses a hypoglycemic effect in diabetic