The article reviews the urgent issue of the allergology, which is the application of the antihistaminic medications. The author has demonstrated the advantages of the 2nd generation medications, which have a selective impact on the H1 receptors and do not cause any sedative or anticholinergic effects. She also showed high efficiency of cetirizine, a representative of the given group, for the treatment of the all year round rhinitis and other allergies.Key words: allergies, pathogenesis, treatment, Н1 receptor blockers, children