Burel-Vandenbos F

Claren A

Clifford SC

Comoglio Y

Doyen J

Durivault J

Feliz Morel AJ

Hanna R

Leloire M

Martial S

Mejias B

Morot A

Pages G

Pagnuzzi M

Penco-Campillo M

Picco V

Selby M

Williamson D

\ua9 2020, The Author(s).Medulloblastoma (MB), the most common brain pediatric tumor, is a pathology composed of four molecular subgroups. Despite a multimodal treatment, 30% of the patients eventually relapse, with the fatal appearance of metastases within 5 years. The major actors of metastatic dissemination are the lymphatic vessel growth factor, VEGFC, and its receptors/co-receptors. Here, we show that VEGFC is inversely correlated to cell aggressiveness. Indeed, VEGFC decreases MB cell proliferation and migration, and their ability to form pseudo-vessel in vitro. Irradiation resistant-cells, which present high levels of VEGFC, lose the ability to migrate and to form vessel-like structures. Thus, irradiation reduces MB cell aggressiveness via a VEGFC-dependent process. Cells intrinsically or ectopically overexpressing VEGFC and irradiation-resistant cells form smaller experimental tumors in nude mice. Opposite to the common dogma, our results give strong arguments in favor of VEGFC as a negative regulator of MB growth

Newcastle University E-Prints

VEGFC negatively regulates the growth and aggressiveness of medulloblastoma cells

VEGFC negatively regulates the growth and aggressiveness of medulloblastoma cells

Abstract

Similar works

Full text

Available Versions

Newcastle University E-Prints