Betancur C

Buxbaum JD

Chiocchetti AG

Cutler DJ

Daly MJ

De Rubeis S

Doan RN

Freitag CM

Goetze S

Lim ET

Overman LM

Soucy A

Walsh CA

Yu TW

\ua9 2019, The Author(s), under exclusive licence to Springer Nature America, Inc. Autism spectrum disorder (ASD) affects up to 1 in 59 individuals1. Genome-wide association and large-scale sequencing studies strongly implicate both common variants2–4 and rare de novo variants5–10 in ASD. Recessive mutations have also been implicated11–14 but their contribution remains less well defined. Here we demonstrate an excess of biallelic loss-of-function and damaging missense mutations in a large ASD cohort, corresponding to approximately 5% of total cases, including 10% of females, consistent with a female protective effect. We document biallelic disruption of known or emerging recessive neurodevelopmental genes (CA2,DDHD1,NSUN2,PAH,RARB,ROGDI,SLC1A1,USH2A) as well as other genes not previously implicated in ASD including FEV (FEV transcription factor, ETS family member), which encodes a key regulator of the serotonergic circuitry. Our data refine estimates of the contribution of recessive mutation to ASD and suggest new paths for illuminating previously unknown biological pathways responsible for this condition

Newcastle University E-Prints

Recessive gene disruptions in autism spectrum disorder

Recessive gene disruptions in autism spectrum disorder

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