Albanes D

Ali M

Andersen NF

Bandapalli OR

Batra J

Benlloch S

Berndt SI

Bertsch U

Brenner H

Broderick P

Broyl A

Campo C

Cancel-Tassin G

Cannon-Albright L

Canzian F

Chanock S

Chen B

Claessens F

Clements J

Conti DV

Cybulski C

da Silva Filho MI

Davies FE

De Ruyck K

Dominguez MG

Donovan JL

Dunning A

Easton D

Eeles RA

Einsele H

Forsti A

Giles GG

Goldschmidt H

Gregory WA

Grindedal EM

Gronberg H

Gudbjartsson DF

Gullberg U

Haiman CA

Halvarsson B-M

Hamdy FC

Hamilton RJ

Hansson M

Hemminki K

Henderson BE

Hillengass J

Hoffmann P

Holroyd A

Houlston RS

Ingles SA

Jackson GH

Jockel K-H

John EM

Johnson DC

Johnsson E

Kaiser M

Kaneva R

Khaw K-T

Kibel AS

Kim J

Kimber S

Kogevinas M

Kote-Jarai ZS

Koutros S

Kristinsson SY

Kuiper R

Langer C

Law PJ

Lessel D

Li N

Lu Y-J

Maier C

Mellqvist U-H

Menegaux F

Mitchell JS

Morgan GJ

Mucci L

Muir K

Nahi H

Neal DE

Neuhausen SL

Newcomb LF

Nickel J

Nilsson B

Nordestgaard BG

Nothen MM

Olama AAA

Orlando G

Pandha H

Park JY

Pashayan N

Penney KL

Peto J

Pharoah P

Rafnar T

Razack A

Roobol MJ

Rosenstein B

Ross FM

Schleutker J

\ua9 2018, The Author(s). Genome-wide association studies (GWAS) have transformed our understanding of susceptibility to multiple myeloma (MM), but much of the heritability remains unexplained. We report a new GWAS, a meta-analysis with previous GWAS and a replication series, totalling 9974 MM cases and 247,556 controls of European ancestry. Collectively, these data provide evidence for six new MM risk loci, bringing the total number to 23. Integration of information from gene expression, epigenetic profiling and in situ Hi-C data for the 23 risk loci implicate disruption of developmental transcriptional regulators as a basis of MM susceptibility, compatible with altered B-cell differentiation as a key mechanism. Dysregulation of autophagy/apoptosis and cell cycle signalling feature as recurrently perturbed pathways. Our findings provide further insight into the biological basis of MM

Went M

Sud A

Weinhold N

van Duin M

Thorleifsson G

Stephens OW

Swerdlow A

Thomsen H

Turesson I

Vangsted A

Waage A

Walker BA

Wihlborg A-K

Thorsteinsdottir U

Sonneveld P

Stefansson K

Schumacher FR

Wiklund F

Stevens VL

Tangen CM

Weinstein S

Wolk A

West C

Sorensen KD

Travis RC

Newcastle University E-Prints

English

Identification of multiple risk loci and regulatory mechanisms influencing susceptibility to multiple myeloma

Identification of multiple risk loci and regulatory mechanisms influencing susceptibility to multiple myeloma

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