Aubry JM

Azorin JM

Bellivier F

Etain B

Golmard JL

Henry C

Jamain S

Leboyer M

Preisig M

Scott J

ObjectiveIt is suggested that age at onset (AAO) of bipolar I disorder (BP-I) is decreasing. We tested for a birth-cohort effect on AAO using admixture analysis.MethodA clinical sample of 3896 BP-I cases was analysed using two approaches: (i) in a subsample with untruncated AAOxbirth year distribution (n=1865), we compared the best-fitting model for the observed AAO in patients born 1960 and &gt;1960, (ii) to control for potential confounders, two separate subsamples born 1960 and &gt;1960 were matched for age at interview (n=250), and a further admixture analysis was undertaken.ResultsThe two approaches indicated that the proportion of cases in the early AAO category was significantly greater in cases born &gt;1960; manic onsets were also more frequent in the early onset BP-I cases born &gt;1960.ConclusionThe decrease in AAO of BP-I in recent birth-cohorts appears to be associated with an increase in the proportion of cases in the early onset subgroup; not with a decrease in the mean AAO in each putative subgroup. This could indicate temporal changes in exposure to risk factors for mania

Newcastle University E-Prints

Using admixture analysis to examine birth-cohort effects on age at onset of bipolar disorder

Using admixture analysis to examine birth-cohort effects on age at onset of bipolar disorder

Abstract

Similar works

Full text

Available Versions

Newcastle University E-Prints